flavonoids from salvia chloroleuca with α-amylsae and α-glucosidase inhibitory effect

Authors

behvar asghari department of plant production and breeding engineering, faculty of engineering and technology, imam khomeini international university, qazvin, iran

peyman salehi department of phytochemistry, medicinal plants and drugs research institute, shahid beheshti university, g. c., tehran, iran

ali sonboli department of biology, medicinal plants and drugs research institute, shahid beheshti university, g. c., tehran, iran.

samad nejad ebrahimi department of phytochemistry, medicinal plants and drugs research institute, shahid beheshti university, g. c., tehran, iran.

abstract

it is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. in our study four flavonoids, namely luteolin 7-o-glucoside (1), luteolin 7-o-glucuronide (2), diosmetin 7-o-glucuronide (3) and salvigenin (4) were isolated from aerial parts of salvia chloroleuca. the inhibitory activity of these compounds against α-amylase and α-glucosidase were evaluated. compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with ic50 values of 18.3, 14.7, and 17.1 µm, respectively. also these compounds exhibited moderate α-amylase activity with ic50 values 81.7, 61.5, and 76.3 µm, respectively.

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Journal title:
iranian journal of pharmaceutical research

جلد ۱۴، شماره ۲، صفحات ۶۰۹-۶۱۵

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